Human activities are highly unsustainable and are the main cause of severe environmental damage, especially in terms of depletion and instability of natural resources. In architectural studies, the current scientific research literature focuses less on and examines the areas of environmental sustainability than other topics, and this requires more extensive. The aim of this study is to examine the concept of biomimicry in architecture with a sustainability approach in residential buildings and, in a way, to explain the conceptual framework of the indexes of biomimetic architecture in sustainable building design in residential buildings. Specifically, the question is about biomimetic architecture indexes lead to sustainability in residential buildings? The research is analytical-descriptive and has an applied purpose. The method of collecting information is library and documentary. First, the basic concepts are examined and the cause-and-effect relationships that form biomimetic architecture are referred to using the content analysis method then the application of biomimicry in architecture is explained. Next, according to the formed literature, the final factor model on this issue is extracted globally and locally from the review of the research background and the collection of researchers' opinions and is finally examined in the fuzzy Delphi method. Findings and results show 7 indexes are influencing the biomimetic architectural Indexes in sustainable building design in the approach of sustainability and finally form by 4/77, process by 4/68, function by 4/67 and modelling by 4/72 average score are most important factors in the subject. In Future studies can examine the relationships between indexes.